We will be making the drive from San Francisco to Vegas in July and would appreciate tips. For a variety of reasons, we need to make the trip fairly quickly but are planning to split it up into 2 days in order to see at least a little scenery. Best route for a 2 day trip? Best area to stop for overnight? Suggestions on a couple of must sees? Thanks for the help!
The fastest way is as others have said is south around the Sierras. The more scenic options involve going through the Sierras and then down the east side. The latter will add 3+ hours to the drive. You indicated you need to make the trip fairly quickly so if that is your priority, then flying in is better. If, on the other hand, you have the 2 days but no more, you have some options:
Scenic vs fast:
1. Fastest is I-80 to Reno and then down 395 for awhile and then east over to 95 to Las Vegas. Taking 95 through W Nevada from Reno is actually faster, but boring. Stick with 395 as far south as you can. For scenery, I'd go all the way to Lone Pine and then over through Death Valley. I've been between Lee Vining and Tonopah and would not recommend it; it's pretty desolate. Spend the night at any of the little towns on the east side of the Sierra; Bridgeport/Lee Vining/Bishop etc or Mammoth Lakes. The latter has the most lodging options with lots of ski condos. All of these will be heavily used in the summer for hiking/mountain biking.
2. I-80 takes you a little north but it's a freeway vs 2 lane highway. The next best road across is probably 50 to Tahoe and then over to 395 or south via 88/89. Scenery wise, it's nicer than I-80 but not as nice as Yosemite.
3. Next is the road through Yosemite and Tioga Pass. This one is the best scenery and is a decent road, but will be very slow with summer tourists. I can't get the mapping sites to give me a time estimate for this route since Tioga Pass is still closed from the winter. It will be much slower and you won't be able to get there early in the day so you will hit the slowest part of the day.
4. The other cross mountain roads; 4 and 108 etc are VERY windy and some sections end up essentially one way roads. They are fine if you know what you are getting into and especially if your destination is a hike in the mountains, but I wouldn't recommend them for your purposes.
Road 395 down the east side of the Sierras is very pretty from the CA border south. The views of the mountains are spectacular and you could stop for some short walks along the way. The section north up to Reno is not that scenic, but it's a balance between speed of the freeway vs scenery.
It all depends on what your priorities are and when you are going. If it's a weekday, and you haven't ever been to Yosemite, I'd go that way and deal with the crowds. I'd get a place to stay in Mammoth Lakes and then crank up the air conditioning and head through Death Valley (I did that in August one time and we had to turn off the air conditioner periodically to keep the car from over heating). If it's a weekend, then I-80 looks better. I assume the Highway 50 up to Tahoe gets pretty bad traffic on weekends in the summer. If it's a weekend, flying looks even better.
Sue