Coming from where?
Don't know where you are coming from, north or south on I65. Either way, I just stayed at the Hampton Inn while my husband was at nearby Jewish Hospital and was favorably impressed. It is just off the I-65 Jefferson St (downtown) exit, the first exit off 65 if coming across bridge from Indiana, or about the last exit before you get to I-71 if you are coming from the south.
We have other favorites in downtown Lville but not as close to the interstate exit.